Product name PolyKoVidone® Crospovidone
USP/EP name crospovidonum, crospovidone
INCI/CTFA Insoluble PVP
CAS NO. 25249-54-1
Properties Hygroscopic; Insoluble in water, acid, alkaline and all other common solvents; Swells rapidly in water without gel formation; Improves flowability and plasticity; Strong particle compressibility; Non-ionic; Chemically inert; Low Peroxide content
Special Type: Based on the distribution of particle size the material is classified as either type A or B:
The particle size of crospovidone (PVPP) strongly influences the disintegration profile of tablets.
• Solubility enhancer; PolyKovidone® increasing the solubility of poorly soluble drugs via co-evaporation processes.
• Suspension stabilizer; PolyKoVidone® increasing the viscosity and improves the dispersion properties to reduce the sedimentation rate of drugs, meanwhile increasing the re-dispersibility of said sediment. Suitable for liquid and instant oral preparations.
• Complexing agent of drug ingredients; PolyKoVidone® stabilizes active ingredients in pharmaceutical products, improving drug solubility and bioavailability.